Dados do Trabalho

Título

Influence of administration of bacteria Lactobacillus plantarum 286 and Lactobacillus plantarum 81 on a behavioral model of anxiety, learning and memory

Fundamentação/Introdução

The consumption of microorganisms capable of modulating the intestinal microbiota has gained visibility in the scientific scenario because it appears to be an alternative in the prevention or as a therapeutic adjunct against mental disorders.

Objetivos

The aim of this study was to evaluate the influence of the chronic consumption of L. plantarum 286 (Lp 286) and L. plantarum 81 (Lp 81) on a behavioral model of anxiety, learning and memory in mice treated and untreated (5 days) with amoxicillin with clavulanic acid.

Delineamento e Métodos

After CEUA-UESC approval No. 012/17, Swiss mice (male) were allocated in 3 groups (N=10/group), who received for 30 days Vehicle, Lp 286 or Lp 81 and then were submitted to the Discriminative Avoidance test. The test was analyzed with the ANYMAZE® software, the ANOVA and Bonferroni post-hoc test. The procedures were repeated in animals previously treated with the antibiotic amoxycillin with clavulanic acid.

Resultados

It was found that antibiotic treatment did not modify the behavior of the animals under the conditions tested. It was also possible to observe that the Lp 286 strain increased the time spent in the open arms of the device, indicating a possible anxiolytic effect (p=0.0180) without interfering in the learning, evaluated by the time of permanence minute by minute in the aversive closed arm (ACA) of the device on the day of training (p=0.8733) and memory, evaluated by the total residence time in the ACA on the day of the test (p=0.3874). The Lp 81 strain did not interfere in the cognitive aspects evaluated and did not present an anxiolytic action (p > 0.05).

Conclusões/Considerações Finais

Thus, the Lp 286 strain presents itself as a probable candidate for psychobiotic in suggesting possible anxiolytic action without interfering with the cognitive aspects. Therefore, shared information corroborates with the ideas published in the literature: there is bi-directional communication between the brain-gut-microbiota, and the modulation of this axis can confer benefits and configure a strategy for the maintenance of physical and mental well-being. This summary was presented at the 2018's SBNeC.

Referências

Palavras-chave

Anxiety, Discriminative Avoidance, Lactobacillus plantarum, Mental Health, Probiotics

Área

Tema livre